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It is no wonder that now the latest idea is to merge prescription medications hoping that while using the combination may have the miraculous results they so desperately want and perhaps need. Using two separate drugs to lose weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you should err to the side of caution and let the FDA do its job and demand some study be done in order that the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to make money and that they would say anything to keep people on their medications. Researchers discovered that participants taking this drug for the year, dropped excess weight within a month and have kept the body weight off throughout the 56 weeks in the study. Contrave is really a combination of the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of many active ingredient, which might make them more effective and safer. Combo-pilling may be the newest fad or better yet the newest in the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is now popular is the fact that at the time of right now there are not any long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug may also raise hypertension and pulse rate, and mustn't be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not be used in patients with uncontrolled high blood pressure, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant if the addict uses the medication properly, but if your tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed inside the liver after that uptake in the intestines and has no therapeutic effect. Buprenorphine may be the active substance; it can be absorbed beneath the tongue (and through the mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I used this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who may have had gastric bypass, where the first area of the intestine is bypassed as well as the stomach contents empty into a more distal part of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy in which the drug is taken up by the duodenum and transferred directly to the liver with the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be taken on by servings of the intestine which aren't served from the portal system, causing blood numbers of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.